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Spore-Forming Probiotics Combat Leaky Gut

Here at Liberty Bion we’re always on the lookout for interesting scientific research that describes the performance of probiotics to improve human health. Recently we came across an article entitled “Oral spore-based probiotic supplementation was associated with reduced incidence of post-prandial dietary endotoxin, triglycerides and disease markers”. In this study, the authors used a combination of spore-based probiotics to fight off chronic immune activation associated with “leaky gut”.

Leaky gut syndrome is thought to be caused by something known as intestinal permeability. This happens when the junctions in the intestines, which control what passes through to the blood stream, do not work properly and inflammatory substances such as bacterial endotoxins “leak” from the gut. Endotoxemia is the medical term used to describe the presence of bacterial endotoxins in the blood stream and amazingly, it affects approximately one-third of people living in the United States and other western societies.

So, why are so many people affected by leaky gut syndrome? In large part, our consumption of high calorie, overly processed and commercially packaged foods is the culprit. In fact, research has shown that a single high-fat, high-calorie meal can cause an increase in all sorts of inflammatory signals such as endotoxins, cytokines, endothelial microparticles, triglycerides and much more. In addition, studies have shown that the presence of this inflammatory milieu in the bloodstream is transient and occurs in the first five hours following the consumption of a high-calorie meal.

So, it appears that the dietary consumption of “junk foods” can disrupt intestinal permeability and/or cause changes to the gut microbiota, resulting in inflammation. When we combine sedentary lifestyle to poor eating habits we are setting the stage for all sorts of inflammatory processes that may eventually lead to serious chronic disease such as obesity, diabetes and neurodegenerative disorders. Clearly, changes in dietary habits to replace highly processed and calorie dense western foods with vegetables and other high-quality foods, combined with exercise, will go a long way to reduce the effects of chronic inflammation caused by endotoxemia and “leaky gut”.

So where to probiotics fit in? According to the authors of the article mentioned above, probiotics can reduce the inflammatory signals produced following a “junk food” meal. To prove this, they identified a group of college-aged volunteers who were known to express high levels of inflammatory signals following a high-fat meal, fed them a thin crust cheese pizza (i.e., 85% of the recommended daily allowance of fat and 65% of the total recommended calorie allowance), and measured inflammatory signals in the blood before and after a 30-day trial of probiotics. They also included a control group of students to received a placebo.

So, what happened? Volunteers who received 30-days of the probiotic supplement experienced a 42% reduction in blood endotoxin levels and a 24% reduction in triglycerides. Keep in mind that the student volunteers did not change their eating and lifestyle habits during this 30-day study and so the authors attribute the anti-inflammatory benefits solely to the probiotic supplementation.

It’s important to point out that the probiotics they used in the study were not the ordinary Lactobacillus and Bifidobacterium strains that we see every day in most probiotic supplements. Rather they used “spore-based” probiotics (or more commonly known, “soil-based organism” probiotics). According to the authors, they wanted to use “spore-based” probiotics because they didn’t believe that normal probiotics using Lactobacillus and Bifidobacterium would be fully viable once they arrived in the intestines. In other words, they were concerned that normal probiotics would be dead, killed by the high acidity of the stomach, before they arrived in the intestines.

Unlike Lactobacillus and Bifidobacterium probiotics strains, Bacillus strains form endospores and are naturally resistant to the high-acidic environment of the stomach. The authors speculate that clinical studies using non-endospore-forming strains (i.e., Lactobacillus and Bifidobacterium) often fail to deliver demonstrable health benefits because they do not arrive alive to the intestines. Fortunately, in this study, the authors used spore-forming Bacillus species and therefore realized a significant reduction in inflammatory signals (i.e., endotoxin, triglycerides and other signals).

At Liberty Bion, we have formulated a probiotic called Hero ProbioticsTM which is specifically designed to deliver a diverse set of beneficial bacteria to your body. Like many probiotic brands, Hero ProbioticsTM contains beneficial strains of Lactobacillus and Bifidobacterium species. However, we have also added spore-forming Bacillus species. In all, we have included 10 strains of healthy probiotics at a CFU count of 30 billion organisms in a daily use supplement.

For a limited time only, purchase a one month supply of Hero Probiotics for 50% off the regular price. Click here to take advantage of this offer.

Below are the 10 health benefits of HeroTM Probiotics:

  1. Helps maintain healthy levels of cholesterol, glucose, triglycerides and blood pressure
  2. Protects against occasional bouts of diarrhea, gas and bloating
  3. Help maintain natural Immune function in healthy individuals
  4. Reduces abdominal pain and bloating
  5. Prevents overgrowth of pathogenic microbes
  6. Helps maintain intestinal barrier function
  7. Promotes proper digestion and nutrient absorption
  8. May provide beneficial effects on mood and psychological stress
  9. May support weight loss efforts
  10. Produces short chain fatty acids that have anti-inflammatory effects

Remember that healthy living requires feeding your gut microbiota to promote diversity. Your efforts to promote good gut health can be supported through diverse and healthy diets and supplementation with the beneficial probiotics found in HeroTM Probiotics.

50% Off on All Soil-Based Organism (SBO) Probiotics

Soil-Based Organisms (SBO) are naturally resistant to the harsh environment of the stomach. Fortify your immune system, revitalize your energy levels and support healthy digestive function with SBO Hero Probiotics.

Leave a Comment:

Lisa says October 6, 2017

How many strains?

    Richard Toal says October 6, 2017

    Hi Lisa:
    Hero Probiotics contains 10 strains including Bacillus subtilis, Bacillus coagulans, Lactobacillus acidophilus, Bifidobacterium lactis, Lactobacillus salivarius, Bifidobacterium longum, Lactobacillus rhamnosus, Lactobacillus casei, Bifidobacterium breve, and Lactobacillus plantarum. You can get more info – including specifics on each strain by visiting the link below and clicking on the formula tab. Thanks.


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